abstract：:ISO 22870 standards require protocols for performance of internal quality control for all point-of-care testing devices and training of users in its theory and practice. However, the unique setting of point-of-care testing (i.e. processes conducted by non-scientific users) means that laboratory internal quality contro...

journal_title：Annals of clinical biochemistry

authors： Holt H,Freedman DB

更新日期：2016-03-01 00:00:00

abstract：AIM:The aim of the study was to review the clinical validation process of out of hours critical biochemistry results by a clinical biochemist and its effect on primary care services. METHODS:A prospective study was conducted of all critical results for primary care patients who were analysed out of hours. The nine-mon...

journal_title：Annals of clinical biochemistry

authors： Chandrajay D,Narayanan D,Barth JH

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Various conjugated cholesterol metabolites are excreted in urine of the patients with metabolic abnormalities and hepatobiliary diseases. We aimed to examine the usefulness of precursor ion scan and neutral loss scan for the characterization of conjugated cholesterol metabolites in urine. METHODS:A mixture ...

journal_title：Annals of clinical biochemistry

authors： Maekawa M,Shimada M,Ohno K,Togawa M,Nittono H,Iida T,Hofmann AF,Goto J,Yamaguchi H,Mano N

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The rapid exclusion of acute myocardial infarction in patients with chest pain can reduce the length of hospital admission, prevent unnecessary diagnostic work-up and reduce the burden on our health-care systems. The combined use of biomarkers that are associated with different pathophysiological aspects of ...

journal_title：Annals of clinical biochemistry

authors： Jacobs LH,van Borren M,Gemen E,van Eck M,van Son B,Glatz JF,Daniels M,Kusters R

更新日期：2015-09-01 00:00:00

abstract：BACKGROUNDS:Diabetic patients with end-stage renal disease who are not on haemodialysis show low concentrations of HbA1c and glycated albumin due to renal anaemia and proteinuria, respectively. In the present study, we examined whether serum albumin-adjusted glycated albumin could accurately reflect glycaemic control i...

journal_title：Annals of clinical biochemistry

authors： Fukami K,Shibata R,Nakayama H,Yamada K,Okuda S,Koga M

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia. METHODS:Serum concentrat...

journal_title：Annals of clinical biochemistry

authors： Liu H,Wu J,Wang H,Sheng L,Tang N,Li Y,Hao T

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Angiogenesis is involved in the pathogenesis of diabetic retinopathy. Osteoprotegerin, a recently identified glycoprotein belonging to the tumour necrosis factor receptor superfamily, has been implicated to be correlated with angiogenesis. This study aims to determine whether serum and vitreous concentration...

journal_title：Annals of clinical biochemistry

authors： Yu G,Ji X,Jin J,Bu S

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:It is not possible to diagnose acute kidney injury (AKI) in early stages with traditional biomarkers. Kidney injury molecule-1 (KIM-1) is a novel biomarker promising the diagnosis of AKI in early stages. We studied whether urinary and serum KIM-1 (KIM-1 U and KIM-1 S ) concentrations were useful in predictin...

journal_title：Annals of clinical biochemistry

authors： Tekce BK,Uyeturk U,Tekce H,Uyeturk U,Aktas G,Akkaya A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Refeeding syndrome (RS) is a potentially fatal condition that can occur following the re-introduction of nutrition after a period of starvation. Hypophosphataemia following the reintroduction of nutrition is often the only reliable biochemical marker of RS. Refeeding index (RI) generated from baseline insuli...

journal_title：Annals of clinical biochemistry

authors： Goyale A,Ashley SL,Taylor DR,Elnenaei MO,Alaghband-Zadeh J,Sherwood RA,le Roux CW,Vincent RP

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis is the method of choice when it comes to the accurate quantification of 25-OH-vitamin D in blood samples. It is generally assumed that the addition of exogenous internal standard allows for the determination of the endo...

journal_title：Annals of clinical biochemistry

authors： Lankes U,Elder PA,Lewis JG,George P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:To know whether metformin improves postprandial hyperglycaemia, we examined the effect of metformin on the glycated albumin (GA) to glycated haemoglobin (HbA1c) ratio (GA/HbA1c ratio) in patients with newly diagnosed type 2 diabetes. METHODS:Metformin and lifestyle interventions were initiated in 18 patient...

journal_title：Annals of clinical biochemistry

authors： Sumitani S,Morita S,Deguchi R,Hirai K,Mukai K,Utsu Y,Miki S,Sato B,Nakamura H,Kasayama S,Koga M

更新日期：2015-01-01 00:00:00

abstract：:We present two cases of spuriously high cerebrospinal fluid glucose concentration with approximately normal blood glucose concentrations. The cause of these abnormal findings was the use of inappropriate collection tubes during the pre-analytical phase. Whilst no patient harm was identified following this error, signi...

journal_title：Annals of clinical biochemistry

authors： Broz P,Rajdl D,Racek J,Petr T,Vitek L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Oxidation of lipoproteins is thought to play a crucial role in atherogenesis. Role for triglyceride-rich lipoproteins in atherogenesis is unclear. Thus, we aimed to investigate whether cholesteryl ester hydroperoxides (CEOOH) are present in very low-density lipoproteins (VLDL) and intermediate-density lipopr...

journal_title：Annals of clinical biochemistry

authors： Shrestha R,Hui SP,Sakurai T,Yagi A,Takahashi Y,Takeda S,Jin S,Fuda H,Chiba H

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:As lifespan in HIV infection increases, cardiovascular disease has emerged as a cause of morbidity and mortality. Asymmetric dimethylarginine is an established marker of endothelial dysfunction and predicts cardiovascular events. The role of asymmetric dimethylarginine in HIV-related cardiovascular disease h...

journal_title：Annals of clinical biochemistry

authors： Hudson CL,Zemlin AE,Ipp H

更新日期：2014-09-01 00:00:00

abstract：:Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the malignant proliferation of a plasma cell clone that produces a monoclonal immunoglobulin. Diagnosis and management of patients with monoclonal gammopathies depend on accurate identification and characterization of monoclonal proteins. We present a 6...

journal_title：Annals of clinical biochemistry

authors： Aksungar FB,Ayer M,Serteser M,Coskun A,Unsal I

更新日期：2014-09-01 00:00:00

abstract：:17-Hydroxyprogesterone (17-OHP) is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase. An inherited deficiency of 21-hydroxylase leads to greatly increased serum concentrations of 17-OHP, while the absence of cortisol synthesis cause...

journal_title：Annals of clinical biochemistry

authors： Honour JW

更新日期：2014-07-01 00:00:00

abstract：:Heterophilic antibodies are well described, but poorly appreciated interferents and is often not a recognized problem affecting most immunoassays. We report a patient presented with ectopic Cushing's syndrome (CS), but repeated plasma adrenocorticotropic hormone (ACTH) concentrations conducted by immunoassay were inap...

journal_title：Annals of clinical biochemistry

authors： Saiegh L,Odeh M,Chen-Konak L,Elias N,Sheikh-Ahmad M,Reut M,Slobodin G,Bejar J,Shechner C

更新日期：2014-07-01 00:00:00

abstract：:We hereby describe the rare case of a 59-year-old patient presenting with marked hyperamylasaemia mimicking acute pancreatitis upon admission. Investigation of co-existent hypokalemia revealed the presence of ectopic adrenocorticotropic hormone secretion, leading to the final diagnosis of small cell lung cancer, exhib...

journal_title：Annals of clinical biochemistry

authors： Akinosoglou K,Siagris D,Geropoulou E,Kosmopoulou O,Velissaris D,Kyriazopoulou V,Gogos C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Combined lipid and glucose point-of-care testing (POCT) devices could facilitate widespread population screening for cardiovascular disease (CVD) and diabetes as part of the NHS Vascular Risk Assessment and Management Program (NHS Health Checks). An evaluation of the Cholestech LDX and CardioChek PA POCT ana...

journal_title：Annals of clinical biochemistry

authors： Whitehead SJ,Ford C,Gama R

更新日期：2014-01-01 00:00:00

abstract：:Background Analysis of dried blood specimens has been an integral part of laboratory medicine dating back to the early 1960s when they were introduced as part of neonatal screening programs. More recently, they have been used in Down syndrome screening programmes. Dried blood spot specimens can be collected either by ...

journal_title：Annals of clinical biochemistry

authors： Krantz DA,Carmichael JB

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Pharmacometabonomics is a new branch of science, first described in 2006 and defined as 'the prediction of the effects of a drug on the basis of a mathematical model of pre-dose metabolite profiles'. Pharmacometabonomics has been used to predict drug metabolism, pharmacokinetics (PK), drug safety and drug ef...

journal_title：Annals of clinical biochemistry

authors： Everett JR,Loo RL,Pullen FS

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Supported liquid extraction (SLE) techniques are relatively new compared to other sample preparation approaches such as solid phase extraction (SPE), liquid-liquid extraction (LLE) and protein precipitation (PPE). We investigated the use of SLE as an alternative to SPE for the liquid chromatography tandem ma...

journal_title：Annals of clinical biochemistry

authors： Owen LJ,Keevil BG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:LC-MS/MS is rapidly becoming the technology of choice for measuring steroid hormones. We have developed a rapid LC-MS/MS assay for the routine analysis of serum cortisol. We have used this assay to investigate the effects of gender and exogenous steroid interference on the immunoassay measurement of serum co...

journal_title：Annals of clinical biochemistry

authors： Owen LJ,Adaway JE,Davies S,Neale S,El-Farhan N,Ducroq D,Evans C,Rees DA,MacKenzie F,Keevil BG

更新日期：2013-07-01 00:00:00

abstract：:Proteinuria is the cardinal sign of renal disease, therefore accurate identification of clinically significant proteinuria is essential to the diagnosis and management of kidney disease. Spot samples are now widely used, namely protein: creatinine ratio (uPCR) and albumin: creatinine ratio (uACR). In this article we r...

journal_title：Annals of clinical biochemistry

authors： Methven S,MacGregor MS

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Neutrophilic polymorphonuclear leukocytes play a crucial role in the host defence against bacterial and fungal infections. They participate in the inflammatory response through the liberation of peptides and enzymes like myeloperoxidase (MPO). Therefore, MPO has a potential as a marker enzyme for the diagnos...

journal_title：Annals of clinical biochemistry

authors： Hasmann A,Wehrschuetz-Sigl E,Marold A,Wiesbauer H,Schoeftner R,Gewessler U,Kandelbauer A,Schiffer D,Schneider KP,Binder B,Schintler M,Guebitz GM

更新日期：2013-05-01 00:00:00

abstract：:Hereditary renal hypouricaemia (HRH) is a genetic disorder commonly associated with exercise-induced acute kidney injury (AKI). We report the case of a 19-year-old man who was admitted to hospital with exercise-induced AKI and who was subsequently shown to have HRH. We believe this to be the first description of a cas...

journal_title：Annals of clinical biochemistry

authors： Chakraborty S,Sural S

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Oxidative stress may play an aetiological role in the development and progression of cardiovascular disease (CVD). However, evidence on its biochemical markers has been controversial. This article aimed to assess the role of F2-isoprostanes, a marker for measuring in vivo lipid oxidation, as a biomarker for ...

journal_title：Annals of clinical biochemistry

authors： Zhang ZJ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The worldwide epidemic of obesity is a major public health concern and is persuasively linked to the rising prevalence of diabetes and cardiovascular disease. Obesity is often associated with an abnormal lipoprotein profile, which may be partly negated by pioglitazone intervention, as this can influence the ...

journal_title：Annals of clinical biochemistry

authors： McEneny J,McPherson PA,McGinty A,Hull SS,McCance DR,Young IS

更新日期：2013-01-01 00:00:00

abstract：:Guaiac-based faecal occult blood tests (gFOBT) are still used in asymptomatic population bowel screening programmes but are being replaced by faecal immunochemical tests (FIT) for haemoglobin. gFOBT have many well-documented disadvantages and there is little evidence for their use in assessment of the symptomatic. Man...

journal_title：Annals of clinical biochemistry

authors： Fraser CG

更新日期：2012-11-01 00:00:00

abstract：:A patient with sepsis and jaundice was admitted for diagnosis and treatment. Associated biochemical changes included increased C-reactive protein, conjugated bilirubin and gamma-glutamyltransferase, the duration of which was protracted. High urine coproporphyrin isomer-1 and immunostaining of liver tissue suggested Du...

journal_title：Annals of clinical biochemistry

authors： Devgun MS,El-Nujumi AM,O'Dowd GJ,Barbu V,Poupon R

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Measurement of serum natriuretic peptides is recommended in patients with suspected heart failure. Assays for N-terminal pro-B-type natriuretic peptide (NT-proBNP) are available on several platforms and can be measured in serum or heparinized plasma. Siemens Healthcare Diagnostics do not recommend the use of...

journal_title：Annals of clinical biochemistry

authors： Peake RW,Turner HE,Leaper W,Deans KA,Hannah A,Croal BL

更新日期：2012-09-01 00:00:00

abstract：:Thyroglobulin (Tg) is a tumour marker for differentiated thyroid cancer. Interpretation requires a knowledge of the current thyrotropin (TSH) concentration as secretion is TSH-dependent. While a raised serum Tg may be indicative of residual or recurrent thyroid cancer, trauma to the thyroid (e.g. surgical, biopsy or d...

journal_title：Annals of clinical biochemistry

authors： Clark P,Franklyn J

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:We evaluated the recently released chemiluminescence assay for 25-hydroxy vitamin D (25-OHD) on the Immunodiagnostic Systems iSYS (IDS-iSYS) automated analyser. METHODS:The IDS-iSYS comparison was performed using patient samples previously measured for 25-OHD by a validated liquid chromatography-tandem mass...

journal_title：Annals of clinical biochemistry

authors： Cluse ZN,Fudge AN,Whiting MJ,McWhinney B,Parkinson I,O'Loughlin PD

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Glycated haemoglobin (HbA1c) concentration is lower relative to glyacemic control in diabetic patients on haemodialysis. However, it is unknown as to whether this is also true for diabetic patients with end-stage renal disease but not on haemodialysis. METHODS:Correlations between HbA1c or glycated albumin ...

journal_title：Annals of clinical biochemistry

authors： Shima K,Chujo K,Yamada M,Komatsu M,Noma Y,Mizuguchi T

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Phlebotomy is a potential cause of preanalytical errors. We have observed phlebotomy in routine practice in a busy Emergency Department, to see how current practice compares with optimal blood sampling. METHODS:Phlebotomy episodes were audited and compared with standard procedures. A computer-based search o...

journal_title：Annals of clinical biochemistry

authors： Berg JE,Ahee P,Berg JD

更新日期：2011-11-01 00:00:00

abstract：:Adverse reactions to foods may arise by a variety of mechanisms, both immune (IgE and non-IgE) and non-immune mediated. This article considers those assays useful in the diagnosis of Type 1 hypersensitivity to foods (IgE-based) and, importantly, discusses those assays where evidence is lacking for their use. In all ca...

journal_title：Annals of clinical biochemistry

authors： Lock RJ,Unsworth DJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Current guidelines define acute myocardial infarction (AMI) by the rise and/or fall of cardiac troponin with ≥1 value above the 99th percentile. Past troponin assays have been unreliable at the lower end of the range. Highly sensitive assays have therefore been developed to increase the clinical sensitivity ...

journal_title：Annals of clinical biochemistry

authors： Aldous SJ,Florkowski CM,Crozier IG,Elliott J,George P,Lainchbury JG,Mackay RJ,Than M,Flaws DF,Borowsky J

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:In a network of laboratories analytical variability between instruments, even of the same type, may exist for reasons beyond the control of laboratory staff. Controlling variability is a prerequisite for the application of shared reference ranges and for ensuring the transferability of patient test results. ...

journal_title：Annals of clinical biochemistry

authors： Jassam N,Lindsay C,Harrison K,Thompson D,Bosomworth MP,Barth JH

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Ischaemia-modified albumin (IMA) is a relatively new marker of ischaemia. IMA has not been studied previously in pleural effusions due to congestive heart failure (CHF). The aim of our study was to assess the diagnostic value of IMA in the pleural fluid (PF) and serum for the identification of pleural effusi...

journal_title：Annals of clinical biochemistry

authors： Ozsu S,Gulsoy A,Karahan SC,Mentese A,Nuhoglu I,Ozlu T

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Measurement of plasma-free metanephrine plus normetanephrine (PFM) is the best screening test for phaeochromocytoma. While clearly raised levels are diagnostic, borderline increases may be associated with factors such as stress and medications, and should prompt a repeat study after interfering factors are w...

journal_title：Annals of clinical biochemistry

authors： Anas SS,Vasikaran SD

更新日期：2010-11-01 00:00:00